Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.628


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2



Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_95794416 2.589 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr18_-_56190980 1.983 NM_005912
MC4R
melanocortin 4 receptor
chr10_+_114033403 1.961 NM_058222
TECTB
tectorin beta
chr4_+_77575276 1.959 NM_020859
SHROOM3
shroom family member 3
chr7_+_89681069 1.911 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr10_-_73518772 1.823 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr10_+_77212524 1.767 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr12_-_10846435 1.716 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr12_-_66839589 1.679 NM_000619
IFNG
interferon, gamma
chr7_+_29486010 1.676 NM_001039936
CHN2
chimerin (chimaerin) 2
chr1_-_150328153 1.657 NM_001008536
TCHHL1
trichohyalin-like 1
chr3_-_156904690 1.565 NM_014996
PLCH1
phospholipase C, eta 1
chr9_-_4142182 1.544 NM_152629
GLIS3
GLIS family zinc finger 3
chr4_+_185063421 1.519 NM_020225
STOX2
storkhead box 2
chr3_-_42280442 1.455 NM_001174138
CCK
cholecystokinin
chr1_-_155936904 1.352 NM_052939
FCRL3
Fc receptor-like 3
chr13_-_27441290 1.335 NM_001265
CDX2
caudal type homeobox 2
chr2_+_204509698 1.315 NM_012092
ICOS
inducible T-cell co-stimulator
chr17_-_25685175 1.274 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr17_+_57811645 1.222 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr2_-_238813365 1.212 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr1_+_156842852 1.206 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr3_+_157491469 1.205 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr4_+_114433551 1.196 ANK2
ankyrin 2, neuronal
chr9_-_21177529 1.175 NM_021068
IFNA4
interferon, alpha 4
chr13_-_27441143 1.169 CDX2
caudal type homeobox 2
chr9_+_21399132 1.162 NM_002170
IFNA8
interferon, alpha 8
chr6_-_101018271 1.148 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr12_+_7755316 1.148 NM_199286
DPPA3
STELLAR
developmental pluripotency associated 3
developmental pluripotency associated 3 pseudogene
chr5_+_79366746 1.126 NM_003248
THBS4
thrombospondin 4
chr10_+_91127792 1.123 NM_001010987
IFIT1B
interferon-induced protein with tetratricopeptide repeats 1B
chr9_-_21340885 1.110 NM_021002
IFNA6
interferon, alpha 6
chr11_-_117552545 1.088 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr11_+_123945102 1.071 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr2_-_238813284 1.054 HES6
hairy and enhancer of split 6 (Drosophila)
chr3_+_45902999 1.047 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr7_+_142629251 1.045 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr13_-_27441423 1.039 CDX2
caudal type homeobox 2
chr12_+_7833261 1.035 NM_024865
NANOG
Nanog homeobox
chr9_+_134843918 1.031 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr9_-_21229975 1.004 NM_002172
IFNA14
interferon, alpha 14
chr5_+_140751666 0.997 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr15_-_76313896 0.989 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr9_-_21197141 0.987 NM_002171
IFNA10
interferon, alpha 10
chr12_-_7547552 0.959 NM_004244
NM_203416
CD163

CD163 molecule

chr18_-_59462469 0.948 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr3_+_99484421 0.918 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr10_-_74863303 0.910 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr13_+_108079570 0.907 NM_001198950
MYO16
myosin XVI
chr3_-_56784634 0.900 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr8_-_93099040 0.889 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_+_135106578 0.875 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr12_+_7833292 0.873 NANOG
Nanog homeobox
chr12_+_20854904 0.871 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr18_+_50646616 0.868 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr12_-_9123126 0.854 A2M
alpha-2-macroglobulin
chr3_+_63403792 0.853 NM_144642
SYNPR
synaptoporin
chr1_-_146492471 0.847 NM_015383
NBPF14
NBPF1
neuroblastoma breakpoint family, member 14
neuroblastoma breakpoint family, member 1
chr13_+_96592051 0.844 MBNL2
muscleblind-like 2 (Drosophila)
chr10_+_124141808 0.840 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chrX_+_135397790 0.840 NM_001727
BRS3
bombesin-like receptor 3
chr12_+_103221590 0.837 NM_001008394
EID3
EP300 interacting inhibitor of differentiation 3
chr9_-_21192201 0.822 NM_021057
IFNA7
interferon, alpha 7
chr4_-_21155376 0.809 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr18_-_26876622 0.807 NM_001941
NM_024423
DSC3

desmocollin 3

chr7_+_37689903 0.807


chr10_-_69125932 0.804 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr4_-_123761615 0.778 NM_021803
IL21
interleukin 21
chrX_+_7147471 0.770 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr4_+_154397975 0.765 TRIM2
tripartite motif containing 2
chr2_-_171631728 0.750 NM_001136555
TLK1
tousled-like kinase 1
chr12_-_69600514 0.738 PTPRR
protein tyrosine phosphatase, receptor type, R
chr4_-_41445479 0.725 PHOX2B
paired-like homeobox 2b
chr6_+_50894397 0.723 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_190552744 0.721 NM_001039152
RGS21
regulator of G-protein signaling 21
chr9_+_6205804 0.715 IL33
interleukin 33
chr11_-_128242342 0.712 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr5_+_140719773 0.709 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr8_-_26780645 0.700


chr2_-_215998181 0.696 FN1
fibronectin 1
chr16_+_74868676 0.696 NM_033401
CNTNAP4
contactin associated protein-like 4
chr13_+_22653059 0.694 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr6_-_76838944 0.693 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr16_+_70646008 0.686 NM_001126102
NM_005143
HP

haptoglobin

chr1_+_116181927 0.685 NHLH2
nescient helix loop helix 2
chrX_-_55037235 0.682 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr3_+_109504021 0.681 NM_007072
HHLA2
HERV-H LTR-associating 2
chrX_-_15312390 0.673 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr5_-_135318420 0.668 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr3_+_99555387 0.660 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr10_-_52315436 0.658 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr4_+_14950657 0.656 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr7_-_107230867 0.654 NM_000111
SLC26A3
solute carrier family 26, member 3
chr1_-_108588186 0.653 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr10_+_123744131 0.646 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_+_102859354 0.645 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chrX_+_135210787 0.640 NM_153834
GPR112
G protein-coupled receptor 112
chr17_+_29606408 0.638 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_-_38810504 0.637 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr16_+_52081836 0.634 RBL2
retinoblastoma-like 2 (p130)
chr3_+_149930656 0.626 NM_032049
AGTR1
angiotensin II receptor, type 1
chr9_-_21156609 0.625 NM_002175
IFNA21
interferon, alpha 21
chr1_-_93172119 0.622


chrX_+_70255128 0.621 NM_005120
MED12
mediator complex subunit 12
chr11_+_113280727 0.609 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_+_12367993 0.608 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr11_-_117552355 0.606 SCN2B
sodium channel, voltage-gated, type II, beta
chr9_+_91409746 0.603 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr14_+_61532293 0.602 NM_031914
SYT16
synaptotagmin XVI
chr8_-_26780665 0.599 ADRA1A
adrenergic, alpha-1A-, receptor
chr14_-_20098929 0.599 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr14_-_106149623 0.597


chr3_-_42892195 0.591 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_-_37397669 0.589 NM_005813
PRKD3
protein kinase D3
chr2_-_20390601 0.583 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr2_-_215949566 0.582 FN1
fibronectin 1
chr12_-_88573949 0.577 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr7_+_129057152 0.575 NM_001040110
NRF1
nuclear respiratory factor 1
chr1_-_3556420 0.566 NM_017818
WDR8
WD repeat domain 8
chr11_-_57171554 0.564 YPEL4
yippee-like 4 (Drosophila)
chr1_-_41398126 0.561 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_+_86785346 0.559 NM_012128
CLCA4
chloride channel accessory 4
chr12_+_54231249 0.557 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr1_-_229071957 0.554 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr15_+_19883745 0.546 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr2_-_200038055 0.544 NM_001172517
SATB2
SATB homeobox 2
chr4_+_74493918 0.542 ALB
albumin
chr4_-_165338312 0.539 NM_012403
ANP32C
acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
chr3_+_99370233 0.539 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr12_-_100128115 0.533 NM_145913
SLC5A8
solute carrier family 5 (iodide transporter), member 8
chr1_-_175400441 0.528 ASTN1
astrotactin 1
chr4_-_41445693 0.526 NM_003924
PHOX2B
paired-like homeobox 2b
chr12_+_54172413 0.523 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chrX_+_141941369 0.516 NM_001009613
SPANXN4
SPANX family, member N4
chr6_-_32605898 0.516 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr15_+_63701322 0.514 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr4_-_74307637 0.509 ANKRD17
ankyrin repeat domain 17
chr8_+_142501188 0.508 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr5_+_140762551 0.507 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr6_-_89984214 0.505 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr8_+_7340777 0.503 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chrX_-_138875342 0.498 NM_001013403
CXorf66
chromosome X open reading frame 66
chr7_-_122126422 0.496 NM_139175
RNF133
ring finger protein 133
chr3_+_99350859 0.493 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr12_-_21379098 0.489 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr1_-_175400573 0.487 NM_004319
NM_207108
ASTN1

astrotactin 1

chr10_-_5436781 0.486 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr3_+_2908920 0.485 NM_175613
CNTN4
contactin 4
chr11_-_35398077 0.484 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_-_45648608 0.482 SRBD1
S1 RNA binding domain 1
chr4_+_120276386 0.482 NM_016599
MYOZ2
myozenin 2
chr3_-_174341653 0.476 NM_031955
SPATA16
spermatogenesis associated 16
chr10_+_124660206 0.475 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr8_-_7297296 0.473 NM_058206
NM_058207
SPAG11B

sperm associated antigen 11B

chr9_-_21132143 0.469 NM_002177
IFNW1
interferon, omega 1
chr12_+_54106304 0.468 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr11_-_102100833 0.467 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr3_-_110155237 0.467 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr2_-_165768798 0.466 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr18_-_59480082 0.466 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr2_+_89715037 0.465


chr12_+_47162552 0.464 NM_152319
C12orf54
chromosome 12 open reading frame 54
chr8_+_120148604 0.461 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr10_-_7699192 0.459 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_-_57927457 0.454 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr4_-_149577404 0.447


chr11_-_58368555 0.445 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr18_+_41448763 0.442 NM_007163
SLC14A2
solute carrier family 14 (urea transporter), member 2
chr3_+_191588354 0.438 NM_006580
CLDN16
claudin 16
chr7_+_45899621 0.438


chr1_+_93072947 0.436 RPL5
ribosomal protein L5
chr1_-_157772420 0.436 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr15_+_36014748 0.434 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr11_+_59804634 0.431 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr10_+_90552466 0.430 NM_001128215
LIPM
lipase, family member M
chr3_-_55489973 0.430 WNT5A
wingless-type MMTV integration site family, member 5A
chr14_-_57030227 0.429 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr6_-_22410993 0.428 NM_001163558
PRL
prolactin
chr13_-_43101608 0.426 NM_001127615
ENOX1
ecto-NOX disulfide-thiol exchanger 1
chr4_-_151993422 0.425


chr10_+_95838801 0.423 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr7_-_16811131 0.423 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr1_-_161380562 0.422 RGS5
regulator of G-protein signaling 5
chr15_+_38296920 0.421 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chrX_+_54483565 0.421 NM_058163
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr22_+_34025267 0.421 NM_001135729
TOM1
target of myb1 (chicken)
chr11_-_19038803 0.414 NM_054030
MRGPRX2
MAS-related GPR, member X2
chr5_-_58331515 0.413 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_59390518 0.410 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chrX_+_10084984 0.403 NM_001830
CLCN4
chloride channel 4
chr4_-_122304925 0.398 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr13_+_112746908 0.396 MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_-_100092003 0.396 NM_016188
ACTL6B
actin-like 6B
chr15_-_39151468 0.395 INO80
INO80 homolog (S. cerevisiae)
chr18_+_61568825 0.394 CDH7
cadherin 7, type 2
chr9_-_111230926 0.392 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_-_119512035 0.390 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr3_+_131761867 0.388 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr7_+_45899080 0.387 IGFBP1
insulin-like growth factor binding protein 1
chr11_-_16380967 0.386 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
35.23 5.65e-05 GO:0001959 regulation of cytokine-mediated signaling pathway
34.67 6.12e-05 GO:0060759 regulation of response to cytokine stimulus
58.23 1.29e-04 GO:0060338 regulation of type I interferon-mediated signaling pathway
28.19 2.49e-03 GO:0060337 type I interferon-mediated signaling pathway
28.19 2.49e-03 GO:0071357 cellular response to type I interferon
27.74 2.66e-03 GO:0034340 response to type I interferon
14.20 5.10e-03 GO:0009615 response to virus
9.28 7.90e-03 GO:0034097 response to cytokine stimulus
12.94 7.97e-03 GO:0045088 regulation of innate immune response
11.89 1.20e-02 GO:0019221 cytokine-mediated signaling pathway
2.05 1.57e-02 GO:0032501 multicellular organismal process
10.73 1.95e-02 GO:0071345 cellular response to cytokine stimulus
6.92 4.03e-02 GO:0051707 response to other organism

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.50 2.00e-03 GO:0044421 extracellular region part
4.66 1.11e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.82 2.63e-03 GO:0005126 cytokine receptor binding
10.99 3.72e-03 GO:0005125 cytokine activity